The role of pentachlorophenol in causing mitochondrial derangement in hexachlorobenzene induced experimental porphyria
โ Scribed by Alberto Masini; Daniela Ceccarelli-Stanzani; Aldo Tomasi; Tommaso Trenti; Ezio Ventura
- Book ID
- 115778380
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 327 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0006-2952
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๐ SIMILAR VOLUMES
Both human porphyria cutanea tarda and experimental hexachlorobenzene-induced porphyria are associated with hepatic injury and are potentiated by excess hepatic iron. The mechanisms whereby cellular injury occurs and the synergistic role of iron overload are unknown. In the present experiments, we s
Male C57Bl/10 mice were chronically fed hexachlorobenzene (HCB) (0.02% of the diet) alone or in combination with a single subcutaneous dose of iron (12.5 mg iron per mouse). After eight weeks the group of mice pretreated with the iron overload was highly sensitized to the porphyrogenic effect of HCB