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The role of paraoxonase (PON1) in the detoxication of organophosphates and its human polymorphism

✍ Scribed by L.G. Costa; W.F. Li; R.J. Richter; D.M. Shih; A. Lusis; C.E. Furlong

Book ID
114009733
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
133 KB
Volume
119-120
Category
Article
ISSN
0009-2797

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Ideally we would like to treat people exposed to nerve agents with an enzyme that rapidly destroys nerve agents. The enzymes considered for such a role include human butyrylcholinesterase (BChE), acetylcholinesterase (AChE), carboxylesterase and paraoxonase (PON1). Success has been achieved in endow