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A polymorphism upstream from the human paraoxonase (PON1) gene and its association with PON1 expression

✍ Scribed by Tadashi Suehiro; Toshihiro Nakamura; Mari Inoue; Tomoko Shiinoki; Yukio Ikeda; Yoshitaka Kumon; Masanori Shindo; Hideo Tanaka; Kozo Hashimoto

Book ID
119438681
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
105 KB
Volume
150
Category
Article
ISSN
0021-9150

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## Abstract Paraoxonase 1 (PON 1) is a high‐density lipoprotein (HDL)‐associated enzyme with antioxidant function protecting low‐density lipoprotein (LDL) from oxidation. PON 1 has two amino acid polymorphisms in coding region; L/M 55 and Q/R 192. These polymorphisms modulate paraoxonase activity o