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The active site of human paraoxonase (PON1)

✍ Scribed by Denis Josse; Oksana Lockridge; Weihua Xie; Cynthia F. Bartels; Lawrence M. Schopfer; Patrick Masson

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
83 KB
Volume
21
Category
Article
ISSN
0260-437X

No coin nor oath required. For personal study only.

✦ Synopsis

Ideally we would like to treat people exposed to nerve agents with an enzyme that rapidly destroys nerve agents. The enzymes considered for such a role include human butyrylcholinesterase (BChE), acetylcholinesterase (AChE), carboxylesterase and paraoxonase (PON1). Success has been achieved in endowing BChE with the ability to hydrolyze organophosphates. The G117H mutant of BCHE hydrolyzes sarin and VX, whereas the double mutant G117H/E197Q hydrolyzes soman (

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