Human hepatocellular carcinomas from patients in Britain, an area of low prevalence of hepatocellular carcinoma and low dietary exposure to aflatoxin B,, were analyzed for mutations in the p53 tumorsuppressor gene. Abnormalities in the pS3 gene were detected in 2 of 19 hepatocellular carcinomas by p
The role of p53 tumor suppressor gene in laryngeal epidermoid carcinomas
โ Scribed by Levent Soylu; Hakan Yurdakul; Semra Paydas; Barlas Aydogan
- Book ID
- 117400901
- Publisher
- SAGE Publications
- Year
- 1995
- Tongue
- English
- Weight
- 116 KB
- Volume
- 113
- Category
- Article
- ISSN
- 0194-5998
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
In this study, we analyzed 10 human squamous cell carcinomas (SCCs) for alterations in the p53 tumor suppressor gene in exons 4 through 9 by single-strand conformation polymorphism (SSCP) analysis. We found that 2 of 10 SCCs displayed unusual SSCP alleles at exon 7 of the p53 gene. Subsequent clonin
The prognostic significance and nature of p53 dysfunction in ovarian carcinoma is unclear. The relation between p53 overexpression, p53 mutations, and their effects on overall survival in primary ovarian carcinoma is explored. ## METHODS. Tumor specimens from 171 consecutive epithelial ovarian ca