Dominant-Negative Mutation of p53 Tumor Suppressor Gene in Endometrial Carcinoma
β Scribed by Noriaki Sakuragi; Atsuko Hirai; Mitsuhiro Tada; Hideto Yamada; Ritsu Yamamoto; Seiichiro Fujimoto; Tetsuya Moriuchi
- Book ID
- 112248715
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 101 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0090-8258
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
BACKGROUND. Specific mutations of the p53 tumor suppressor gene in hepatocellular carcinoma (HCC) have been reported from several parts of the world, but to the authors' knowledge to date the status of this gene has not been studied in HCC patients in India, where HCC is one of the major cancers and
## Abstract Although carcinoma of the uterine endometrium is the most frequently diagnosed malignancy of the female reproductive tract, the molecular genetic features of this tumor have yet to be described in significant detail. Since mutations of the __p53__ tumor suppressor gene are the single mo
Transgenic mice deficient for the p53 gene were reported to frequently develop angiosarcoma (AS), suggesting that alterations in the gene are associated with tumorigenesis of AS. However, little is known about genetic changes, including p53 gene alterations, in human AS because of its rarity. We ana
## Abstract In addition to the loss of function, mutant p53 can possess a dominantβnegative effect on wildβtype p53 and may also exert gainβofβfunction activity. It is not clear whether the functional status of __p53__ mutation contributes to differences in outcome in endometrial cancer. We collect
Mutations in the p53 gene are associated with a wide variety of human malignancies. Point mutation in one allele and loss of the remaining one generally lead to inactivation of p53 protein. A high frequency of allelic losses corresponding to the I7p 13.3 region that contained the p53 gene sequence