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The Role of the Tumor Suppressor Gene p53 in Cardiomyocyte Apoptosis

โœ Scribed by Michael T. Crow; Xilin Long; Mario B. Guglielmi; Toshinobu Asai; Edward G. Lakatta

Book ID
110279741
Publisher
Springer
Year
1998
Tongue
English
Weight
280 KB
Volume
3
Category
Article
ISSN
1382-4147

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Transgenic mice deficient for the p53 gene were reported to frequently develop angiosarcoma (AS), suggesting that alterations in the gene are associated with tumorigenesis of AS. However, little is known about genetic changes, including p53 gene alterations, in human AS because of its rarity. We ana