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The role of lithium salts in controlling the regiochemistry of the alkylation of a lithium enolate in a weakly polar aprotic solvent

โœ Scribed by Jackman, L. M.; Dunne, T. S.

Book ID
126792587
Publisher
American Chemical Society
Year
1985
Tongue
English
Weight
302 KB
Volume
107
Category
Article
ISSN
0002-7863

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๐Ÿ“œ SIMILAR VOLUMES

Enantioselective alkylation of lactams a
Enantioselective alkylation of lactams and lactones via lithium enolate formation using a chiral tetradentate lithium amide in the presence of lithium bromide
โœ Jun-ichi Matsuo; Shu Kobayashi; Kenji Koga ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 210 KB

Enantioselective alkylation of lactams and lactones can be realized up to 98% ee by deprotonation with a chiral tetradentate lithium amide (4b) in the presence of lithium bromide, and subsequent alkylation with active alkylating agents in non-chelating solvents.