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Enantioselective alkylation of lactams and lactones via lithium enolate formation using a chiral tetradentate lithium amide in the presence of lithium bromide

✍ Scribed by Jun-ichi Matsuo; Shu Kobayashi; Kenji Koga

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 210 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)02235-7

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✦ Synopsis

Enantioselective alkylation of lactams and lactones can be realized up to 98% ee by deprotonation with a chiral tetradentate lithium amide (4b) in the presence of lithium bromide, and subsequent alkylation with active alkylating agents in non-chelating solvents.

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