๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Stereoselective reactions. 30. Enantioselective alkylation of the lithium enolates of six-membered cyclic ketones using tetradentate chiral amines in the presence of lithium bromide

โœ Scribed by Masatoshi Murakata; Tatsuro Yasukata; Takumi Aoki; Makoto Nakajima; Kenji Koga

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
592 KB
Volume
54
Category
Article
ISSN
0040-4020

No coin nor oath required. For personal study only.

โœฆ Synopsis

An efficient enantioselective alkylation of the lithium enolates of cyclohexanone and ltetralone with reactive alkyl halides was realized using a stoichiometric amount of a tetradentate chiral amine as a ligand for the lithium in the presence of lithium bromide in toluene.

๐Ÿ“œ SIMILAR VOLUMES

Enantioselective alkylation of lactams a
Enantioselective alkylation of lactams and lactones via lithium enolate formation using a chiral tetradentate lithium amide in the presence of lithium bromide
โœ Jun-ichi Matsuo; Shu Kobayashi; Kenji Koga ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 210 KB

Enantioselective alkylation of lactams and lactones can be realized up to 98% ee by deprotonation with a chiral tetradentate lithium amide (4b) in the presence of lithium bromide, and subsequent alkylation with active alkylating agents in non-chelating solvents.