The role of K+ and Cl− conductances in chloride secretion by the opercular epithelium
✍ Scribed by Degnan, Kevin J.
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 568 KB
- Volume
- 236
- Category
- Article
- ISSN
- 0022-104X
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## Abstract The effects of ion substitutions on the Cl^−^ secretion rate and tissue conductance of isolated short‐circuited opercular epithelia from sea‐water‐adapted __Fundulus heteroclitus__ were investigated. Serosal Na^+^ substitution had the same effect on the Cl^−^ secretion rate that serosal
The isolated, short-circuited opercular epithelium of Fundulus heteroclitus, secretes Cl- by a mechanism dependent on the presence of serosal Na+ and inhibited by bumetanide and furosemide. Under serosal Na+-free conditions the active Cl- secretion is abolished. However, subsequent elevations of int