## Abstract Treatment of rats with 100 mg kg^β1^ __t__βbutyl hydroperoxide led to an enhanced ethane exhalation as a marker of __in vivo__ lipid peroxidation, as well as a moderate hepatoxicity as evidenced by a rise in plasma activities of liverβspecific enzymes (glutamateβpyruvate transaminase an
The role of iron in the paracetamol- and CCl4-induced lipid peroxidation and hepatotoxicity
β Scribed by Maged Younes; Claus-Peter Siegers
- Book ID
- 114009310
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 495 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0009-2797
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Research into the pathogenesis of acetaminophen (paracetamo1)-induced hepatotoxicity has concentrated on the generation of toxic metabolites by the hepatocytes. It has, however, recently been shown that human macrophages cultured with acetaminophen secrete increased quantities of tumour necrosis fac