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The Role of Heparan Sulfate Proteoglycans in the Pathogenesis of Alzheimer's Disease

✍ Scribed by D. H. SMALL; T. WILLIAMSON; G. REED; H. CLARRIS; K. BEYREUTHER; C. L. MASTERS; V. NURCOMBE

Book ID: 119873381
Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 322 KB
Volume: 777
Category: Article
ISSN: 0890-6564
DOI: 10.1111/j.1749-6632.1996.tb34439.x

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## Abstract Accumulating evidence indicates that the heparan‐sulfate‐proteoglycan (perlecan, HSPG2), as well as other specific proteoglycans, are involved in amyloidogenesis and tau aggregation in Alzheimer's disease (AD). Moreover, the HSPG2 is located on chromosome 1p36, a region of linkage to la