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Heparan sulfate proteoglycan 2 polymorphism in Alzheimer's disease and correlation with neuropathology

✍ Scribed by Susan Iivonen; Seppo Helisalmi; Arto Mannermaa; Irina Alafuzoff; Maarit Lehtovirta; Hilkka Soininen; Mikko Hiltunen

Book ID
116766030
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
94 KB
Volume
352
Category
Article
ISSN
0304-3940

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An association study of a polymorphism in the heparan sulfate proteoglycan gene (perlecan,HSPG2) and Alzheimer's disease
✍ Rosenmann, Hanna ;Meiner, Zeev ;Kahana, Esther ;Aladjem, Zoja ;Friedman, Gideon πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 62 KB πŸ‘ 3 views

## Abstract Accumulating evidence indicates that the heparan‐sulfate‐proteoglycan (perlecan, HSPG2), as well as other specific proteoglycans, are involved in amyloidogenesis and tau aggregation in Alzheimer's disease (AD). Moreover, the HSPG2 is located on chromosome 1p36, a region of linkage to la