Crucial role of heparan sulfate proteoglycan (agrin) in β-amyloid formation in Alzheimer's disease
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 120 KB
- Volume
- 247
- Category
- Article
- ISSN
- 0340-5354
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## Abstract Accumulating evidence indicates that the heparan‐sulfate‐proteoglycan (perlecan, HSPG2), as well as other specific proteoglycans, are involved in amyloidogenesis and tau aggregation in Alzheimer's disease (AD). Moreover, the HSPG2 is located on chromosome 1p36, a region of linkage to la