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Sulfation of heparan sulfate associated with amyloid-β plaques in patients with Alzheimer’s disease

✍ Scribed by Ilona B. Bruinsma; Luuk te Riet; Tom Gevers; Gerdy B. ten Dam; Toin H. van Kuppevelt; Guido David; Benno Küsters; Robert M. W. de Waal; Marcel M. Verbeek

Publisher: Springer-Verlag
Year: 2009
Tongue: English
Weight: 427 KB
Volume: 119
Category: Article
ISSN: 0001-6322
DOI: 10.1007/s00401-009-0577-1

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## Abstract Accumulating evidence indicates that the heparan‐sulfate‐proteoglycan (perlecan, HSPG2), as well as other specific proteoglycans, are involved in amyloidogenesis and tau aggregation in Alzheimer's disease (AD). Moreover, the HSPG2 is located on chromosome 1p36, a region of linkage to la