After cultivation of dissociated rat testicular tissues, H-Y antigen is detectable in the medium; this is not the case if nongonadal male tissues are incubated. Release of H-Y antigen by testis cells is inhibited by the addition of cycloheximide. All tissues still type H-Y positive after culture. It
The role of H-Y as a minor transplantation antigen
โ Scribed by Elizabeth Simpson
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- English
- Weight
- 854 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0167-5699
No coin nor oath required. For personal study only.
โฆ Synopsis
H-Y antigen is expressed in mammals only by males, so that grafts of male tissue are rejected by females within certain highly inbred strains. H-Y antigen appears to be a simple, non-polymorphic antigen and the genetic control of anti-H-Y responses has been extensively studied. In this article Elizabeth Simpson discusses the many insights obtained.
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## Abstract The tumorโassociated transplantation antigen (TATA), alien Hโ2^k^ antigens and normal Hโ2^d^ antigens expressed on a methylcholanthreneโinduced tumor were monitored during gel filtration and lectin affinity chromatography of detergentโsolubilized tumorโcell membranes. TATA was resolved