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The testis as a secretory organ for H-Y antigen

✍ Scribed by U. Müller; J. W. Siebers; Maria Teresa Zenzes; U. Wolf

Publisher
Springer
Year
1978
Tongue
English
Weight
229 KB
Volume
45
Category
Article
ISSN
0340-6717

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✦ Synopsis

After cultivation of dissociated rat testicular tissues, H-Y antigen is detectable in the medium; this is not the case if nongonadal male tissues are incubated. Release of H-Y antigen by testis cells is inhibited by the addition of cycloheximide. All tissues still type H-Y positive after culture. It is assumed that the testis actively secretes H-Y antigen. This assumption is supported by the finding that the amount of H-Y antigen in the epididymal fluid increases with the age of the animals.

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✍ Elizabeth Simpson 📂 Article 📅 1982 🏛 Elsevier Science 🌐 English ⚖ 854 KB

H-Y antigen is expressed in mammals only by males, so that grafts of male tissue are rejected by females within certain highly inbred strains. H-Y antigen appears to be a simple, non-polymorphic antigen and the genetic control of anti-H-Y responses has been extensively studied. In this article Eliza