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The Role of Glucuronidation in 7-Ethyl-10-hydroxycamptothecin Resistancein vitro

✍ Scribed by Takahashi, Toshiaki ;Fujiwara, Yasuhiro ;Yamakido, Michio ;Katoh, Osamu ;Watanabe, Hiromitsu ;Mackenzie, Peter I.


Book ID
108581382
Publisher
Wiley (Blackwell Publishing)
Year
1997
Tongue
English
Weight
442 KB
Volume
88
Category
Article
ISSN
0910-5050

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High-performance liquid chromatographic
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## Abstract A simple and sensitive assay for glucuronidation activity of 7‐ethyl‐10‐hydroxycamptothecin (SN‐38), the active metabolite of irinotecan (CPT‐11), in human liver microsomes by high‐performance liquid chromatography (HPLC) with fluorescence detection is reported. The method was validated