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Determination of the glucuronide metabolites of the topoisomerase I inhibitors 7-Ethyl 10-hydroxycamptothecin (SN-38) and NU/ICRF 505 by high-performance liquid chromatography

✍ Scribed by J. Cummings; B. T. Ethell; G. Boyd; B. Burchell; J. F. Smyth; D. I. Jodrell

Book ID: 105594837
Publisher: Springer
Year: 2002
Tongue: English
Weight: 629 KB
Volume: 55
Category: Article
ISSN: 0009-5893
DOI: 10.1007/bf02493373

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## Abstract A simple and sensitive assay for glucuronidation activity of 7‐ethyl‐10‐hydroxycamptothecin (SN‐38), the active metabolite of irinotecan (CPT‐11), in human liver microsomes by high‐performance liquid chromatography (HPLC) with fluorescence detection is reported. The method was validated