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Glucuronidation of 7-Ethyl-10-hydroxycamptothecin (SN-38) by the Human UDP-Glucuronosyltransferases Encoded at the UGT1 Locus

✍ Scribed by Marco Ciotti; Nikhil Basu; Mariafiorella Brangi; Ida S. Owens

Book ID: 115583560
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 102 KB
Volume: 260
Category: Article
ISSN: 0006-291X
DOI: 10.1006/bbrc.1999.0453

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## Abstract A simple and sensitive assay for glucuronidation activity of 7‐ethyl‐10‐hydroxycamptothecin (SN‐38), the active metabolite of irinotecan (CPT‐11), in human liver microsomes by high‐performance liquid chromatography (HPLC) with fluorescence detection is reported. The method was validated