Confluent cultures of human endothelial cells deposit into extracellular matrix (ECM) distinct heparan sulfate proteoglycans (HSPG) which modulate acidic fibroblast growth factor's (aFGF) ability to stimulate human endothelial cell mitogenic capacity. Extracellular matrix 'IS-HSPG were isolated from
The Role of Extracellular Matrix Heparan Sulfate Glycosaminoglycan in the Activation of Growth Factor Signaling Pathways
โ Scribed by DONALD P. BOTTARO
- Book ID
- 111397407
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 77 KB
- Volume
- 961
- Category
- Article
- ISSN
- 0890-6564
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
A synthetic peptide, which was shown to bind extracellular matrix heparan sulfate chains with a high degree of affinity and specificity [Colburn et al. (1996): Arch Biochem Biophys 325:129-138], has now been found to promote the transfer and the deposition of endothelial cell surface proteoglycans i
Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix โ secreted macromolecules that interact to form large protein networks outside the cell. During development, the