Cellular Specificity for the Activation of Fibroblast Growth Factor-2 by Heparan Sulfate Proteoglycan
β Scribed by M.M. Fiore
- Book ID
- 115588047
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 90 KB
- Volume
- 284
- Category
- Article
- ISSN
- 0006-291X
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Confluent cultures of human endothelial cells deposit into extracellular matrix (ECM) distinct heparan sulfate proteoglycans (HSPG) which modulate acidic fibroblast growth factor's (aFGF) ability to stimulate human endothelial cell mitogenic capacity. Extracellular matrix 'IS-HSPG were isolated from
## Abstract ## Objective Rheumatoid arthritis (RA) is characterized by progressive joint destruction. The aim of this study was to clarify the relevance of RA synovial fibroblasts (RASFs) and fibroblast growth factor 2 (FGFβ2), which is produced abundantly by RASFs, to the osteoclastogenesis and b