The role of epigenetic inactivation of 14-3-3σ in human cancer
✍ Scribed by LODYGIN, Dmitri; HERMEKING, Heiko
- Book ID
- 110020635
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 386 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0007-0610
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Runt domain transcription factors are important targets of TGF‐β superfamily proteins and play a crucial role in mammalian development. Three mammalian runt‐related genes, __RUNX1__, __RUNX2__ and __RUNX3__, have been described. __RUNX3__ has been shown to be a putative tumor suppressor
## Abstract 14‐3‐3 σ, the downstream target of p53, is a negative regulator of cell cycle G2‐M phase checkpoint in response to DNA damage. Our previous comparative proteomics study showed that 14‐3‐3 σ was downregulated or lost in nasopharyngeal carcinoma (NPC) tissue compared with non‐cancerous na