Epigenetic inactivation of the candidate 3p21.3 suppressor gene BLU in human cancers
✍ Scribed by Agathanggelou, Angelo; Dallol, Ashraf; Zöchbauer-Müller, Sabine; Morrissey, Catherine; Honorio, Sofia; Hesson, Luke; Martinsson, Tommy; Fong, Kwun M; Kuo, Michael J; Yuen, Po Wing
- Book ID
- 110067361
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 493 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0950-9232
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## Abstract Nonrandom allelic loss on chromosome 3p is a common event in nasopharyngeal carcinoma (NPC) with the implication that certain tumor suppressor gene(s) in this region are involved in the pathogenesis of these tumors. The __BLU__ gene, located at 3p21.3, has recently been identified as a
## Abstract Allelic loss on the short arm of chromosome 3 is one of the most common events in the pathogenesis of lung cancer. The lactotransferrin gene (__LTF,__ also referred to as the lactoferrin gene, __LF__) is located at 3p21.3 common eliminated region 1, which is frequently deleted in lung a
## Abstract Chromosome 3p plays an important role in tumorigenesis in many cancers, including nasopharyngeal carcinoma (NPC). We have previously shown chromosome 3p can suppress tumor growth __in vivo__ by using the monochromosome transfer approach, which indicated the chromosome 3p21.3 region was