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Epigenetic inactivation of the candidate tumor suppressor gene HOXB13 in human renal cell carcinoma

✍ Scribed by Okuda, H; Toyota, M; Ishida, W; Furihata, M; Tsuchiya, M; Kamada, M; Tokino, T; Shuin, T

Book ID: 110070233
Publisher: Nature Publishing Group
Year: 2005
Tongue: English
Weight: 425 KB
Volume: 25
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1209200

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## Abstract Extensive hypermethylation and consecutive transcriptional silencing of tumorsuppressor genes have been documented in multiple tumor entities including breast cancer. In a microarray based genome‐wide methylation analysis of five sporadic breast carcinomas we identified a hypermethylate