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Genetic and epigenetic inactivation of LTF gene at 3p21.3 in lung cancers

✍ Scribed by Hironobu Iijima; Yoshio Tomizawa; Yasuki Iwasaki; Koji Sato; Noriaki Sunaga; Kunio Dobashi; Ryusei Saito; Takashi Nakajima; John D. Minna; Masatomo Mori

Publisher: John Wiley and Sons
Year: 2005
Tongue: French
Weight: 223 KB
Volume: 118
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.21462

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✦ Synopsis

Abstract

Allelic loss on the short arm of chromosome 3 is one of the most common events in the pathogenesis of lung cancer. The lactotransferrin gene (LTF, also referred to as the lactoferrin gene, LF) is located at 3p21.3 common eliminated region 1, which is frequently deleted in lung and other cancers. The expression of the LTF gene was absent in 16 (59%) of 27 small cell lung cancer cell lines, 33 (77%) of 43 nonsmall‐cell lung cancer (NSCLC) cell lines and 7 (54%) of 13 primary NSCLC, while LTF mRNA was overexpressed in 3 (7%) of 43 NSCLC cell lines. Its expression was restored by treatment with 5‐aza‐2′‐deoxycytidine (5‐aza‐dC), trichostatin A (TSA) or a combination of both in a subset of lung cancer cell lines without LTF expression. In addition, we found 8 different types of nucleotide substitutions and one frameshift mutation. These results indicate that the LTF gene is inactivated by genetic and epigenetic mechanisms in lung cancer. © 2005 Wiley‐Liss, Inc.

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