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The role of enteric bacteria in the anerobic metabolism of 5-aminosalicylate

✍ Scribed by Tucker, Mark A. ;Bisesi, Michael S. ;Smith, Timothy J.

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 129 KB
Volume: 4
Category: Article
ISSN: 0887-2082
DOI: 10.1002/jbt.2570040411

No coin nor oath required. For personal study only.

✦ Synopsis

The primary (and inactive) enteric metabolite of 5aminosalicylate is N-acetyl-5-aminosalicylate. Previous studies have demonstrated acetylation of this anti-inflammatory agent by intestinal and bacterial homogenates. To assess the contribution of anerobic bacteria to the N-acetylation in vivo, we have measured the production of N-acetyl-5- aminosalicylate in anerobic microculture. Our results indicate that enteric bacteria play a minor role in Nacetylation, but may contribute to the production of other metabolites of pharmacologic and toxicological interest.

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