Newly synthesized MHC class II (x and 13 chains associate with a protein chaperone, the invariant chain, which promotes the proper assembly of MHC class II complexes and their trafficking through cells and prevents their untimely loading with peptides. Efficient loading of MHC class II heterodimers
The role of endosomes and lysosomes in MHC class II functioning
β Scribed by Hans J. Geuze
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 397 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0167-5699
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β¦ Synopsis
Coming soon in IT
β’ Helicobacter pylori: a possible role initiating autoimmune gastritis and pernicious anaemia β’ CD1 peptides -lipid antigen presentation to T cells β’ Allergy and asthma: the genetics of complex disease β’ Heat shock proteins -immunoregulation of the T-cell response in inflammatory disease β’ The effects of virion-bound host-derived proteins on HIV-1 infection β’ Regulation of transcription of MHC class I and class II genes -a role for CIITA and RFX β’ Potent allergenicity of Der p 1 due to cleavage of CD23 and CD25 Don't miss these and many other articles of interest: subscribe to Immunology Today.
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The mechanism by which particular MHC class II alleles mediate susceptibility to a given autoimmune disease is unknown. During the past year, reports have indicated that the effects of MHC class II alleles which protect against type I diabetes in the nonobese diabetic mouse strain may, in some cases