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The bio-logical role of invariant chain (Ii) in MHC class II antigen presentation

✍ Scribed by Tommy W. Nordeng; Oddmund Bakke


Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
864 KB
Volume
43
Category
Article
ISSN
0165-2478

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The invariant chain (Ii) has been shown to play a critical role in the assembly, intracellular transport and function of MHC class II molecules. Recent studies suggest that these distinct activities can in many cases be attributed to distinct isoforms of Ii or to specific regions within it. Thus, re

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Proteolysis of the invariant chain (li) leads to the generation of abundant MHC class II-associated invariant chain peptides (CLIP), which bind in the MHC class II binding groove via supermotifs in a manner similar to that of antigenic peptides. We have engineered an li vector with the capacity to e