The role of MHC class II molecules in susceptibility and resistance to autoimmunity

✍ Scribed by Hugh O McDevitt

• Publisher: Elsevier Science
• Year: 1998
• Tongue: English
• Weight: 385 KB
• Volume: 10
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/s0952-7915(98)80088-5

✦ Synopsis

The mechanism by which particular MHC class II alleles mediate susceptibility to a given autoimmune disease is unknown. During the past year, reports have indicated that the effects of MHC class II alleles which protect against type I diabetes in the nonobese diabetic mouse strain may, in some cases, be due to negative selection of diabetogenic T cell receptors and, in other cases, to positive selection of other T cells with a suppressive action on the diabetic process. Progress towards understanding the mechanisms of susceptibility continues to lag.