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The Role of Drug Metabolism in Drug Discovery and Development : Opportunities to Enhance Time- and Cost-efficiency*

โœ Scribed by JOHN CALDWELL


Book ID
118109987
Publisher
Pharmaceutical Press
Year
1996
Tongue
English
Weight
245 KB
Volume
2
Category
Article
ISSN
2042-7158

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Role of drug metabolism in drug discover
โœ Gondi N. Kumar; Sekhar Surapaneni ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 300 KB ๐Ÿ‘ 1 views

## Abstract Metabolism by the host organism is one of the most important determinants of the pharmacokinetic profile of a drug. High metabolic lability usually leads to poor bioavailability and high clearance. Formation of active or toxic metabolites will have an impact on the pharmacological and t