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The role of cyclodextrins in chiral capillary electrophoresis

✍ Scribed by Zoltán Juvancz; Rita Bodáné Kendrovics; Róbert Iványi; Lajos Szente

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
400 KB
Volume
29
Category
Article
ISSN
0173-0835

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✦ Synopsis

Abstract

The members of the enantiomeric pairs frequently show rather different biological effects, so their chiral selective synthesis, pharmacological studies and analysis are necessary. CE has unique advantages in chiral analysis. The most frequently used chiral selectors are CDs in this field. This paper gives a short view on the advantages on CE in direct chiral separations, emphasizing the role of CDs. The reason for the broad selectivity spectra of CDs is discussed in detail. The physical background of chiral selective separations is briefly shown in CE. Their interaction mechanisms are shortly defined. The general trend of their use is statistically evaluated. Most frequently used CDs and CD derivatives are characterized. Advantages of ionizable CDs and single‐isomer derivatives are shown. The general trend of their use is established.

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## Enantioseparation of chiral thiobarbiturates using cyclodextrin-modified capillary electrophoresis The racemates of several chiral thiobarbiturates were separated by using different cyclodextrins in capillary electrophoresis (CE). Six neutral and negatively charged cyclodextrins 1 (CDs) were em

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## Abstract An immobilized chiral stationary phase, Chirasil‐Dex, coated onto the inner surface of a 50 μm i.d. capillary and cyclodextrin derivatives added to the running buffer were simultaneously used for the study of enantiomer separations by capillary electrophoresis. Dependent on the cyclodex