Experimental data are reviewed that lend support to the hypothesis that formation of DNA damage is the initiation event of local suppression of contact hypersensitivity (CHS) after exposure to ultraviolet (UV) radiation and that the antigen-presenting cell (APC) is an important target for this DNA d
The role of cis-urocanic acid in UVB-induced suppression of contact hypersensitivity
β Scribed by Seiji Kondo; Daniel N. Sauder; Roderick C. McKenzie; Hiroshi Fujisawa; Gulnar M. Shivji; Ali El-Ghorr; Mary Norval
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 515 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0165-2478
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π SIMILAR VOLUMES
UV-B radiation suppresses cell-mediated immunity. Histidine forms trans-urocanic acid (truns-UCA) enzymatically in the stratum comeum. Photoisomerization of trans-UCA to cis-urocanic acid (cis-UCA) has been proposed for the initiation of an immunosuppressive process. Many microorganisms described in
regarding such properties as the surface electrostatic potential and the physicochemical character of the antigen binding groove, both of which are pivotal in antigenic peptide affinity 8,9 . By contrast, few differences have been found between the molecular properties of HLA-DR alleles deemed susce
Healthy volunteers (n = 14, age range 20-31 years, mean 23) were irradiated on the inside of the left forearm on four consecutive days with their individual minimal erythemal dose of ultraviolet B (UVB) prior to sensitization in the same skin area with a 2% solution of diphenylcyclopropenone (DPCP).
The ability of tumor promoters to suppress the development of contact hypersensitivity (CHS) was assessed by the mouse ear swelling assay. Application of the complete or second stage tumor promoters phorbol-12myristate-13-acetate (PMA, 2 pg), croton oil (1%). benzoyl peroxide (20 mg), mezerein ( 2 p