Cellular target of UVB-induced DNA damage resulting in local suppression of contact hypersensitivity

✍ Scribed by Arie A. Vink; Vijay Shreedhar; L. Roza; Jean Krutmann; Margaret L. Kripke

• Publisher: Elsevier Science
• Year: 1998
• Tongue: English
• Weight: 556 KB
• Volume: 44
• Category: Article
• ISSN: 1011-1344
• DOI: 10.1016/s1011-1344(98)00128-6

✦ Synopsis

Experimental data are reviewed that lend support to the hypothesis that formation of DNA damage is the initiation event of local suppression of contact hypersensitivity (CHS) after exposure to ultraviolet (UV) radiation and that the antigen-presenting cell (APC) is an important target for this DNA damage.