✦ LIBER ✦

The role of CD4+ T cell responses in antitumor immunity

✍ Scribed by Drew M Pardoll; Suzanne L Topalian

Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 630 KB
Volume: 10
Category: Article
ISSN: 0952-7915
DOI: 10.1016/s0952-7915(98)80228-8

No coin nor oath required. For personal study only.

✦ Synopsis

While most of the focus in cancer immunology is on CD8+ cytotoxic T lymphocyte responses, recent evidence indicates that CD4+ T cells are an equally critical component of the antitumor immune response. Successful immunity to cancer will therefore require activation of tumor-specific CD4+ T cells. Tumor antigens recognized by CD4+ T cells that are restricted by MHC class II are beginning to be defined in both murine and human tumors. These will provide the basis for new generations of antigen-specific tumor vaccines.

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