Immune regulation: a new role for the CD8+ T cell
β Scribed by D.Michael Kemeny; Alistair Noble; Beverly J. Holmes; David Diaz-Sanchez
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 493 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0167-5699
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π SIMILAR VOLUMES
While most of the focus in cancer immunology is on CD8+ cytotoxic T lymphocyte responses, recent evidence indicates that CD4+ T cells are an equally critical component of the antitumor immune response. Successful immunity to cancer will therefore require activation of tumor-specific CD4+ T cells. Tu
CD4, CD8 and CD45 regulate the coupling of the T-cell receptor complex (CD3-TCR) to tyrosine kinase activation and phosphorylation of key substrates such as phospholipase C gamma 1. CD4 and CD8 contribute to activation signals through their cytoplasmic association with p56lck. Expression of the zeta