✦ LIBER ✦

The role of CD22 and other inhibitory co-receptors in B-cell activation

✍ Scribed by Lars Nitschke

Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 1012 KB
Volume: 17
Category: Article
ISSN: 0952-7915
DOI: 10.1016/j.coi.2005.03.005

No coin nor oath required. For personal study only.

✦ Synopsis

Inhibitory co-receptors downmodulate B-cell receptor (BCR) signalling by setting a signalling threshold that prevents overstimulation of B cells. Activation of these inhibitory co-receptors occurs by phosphorylation on their cytoplasmic inhibitory immunoreceptor tyrosine-based inhibition motifs (ITIMs), followed by recruitment of the tyrosine phosphatase SHP-1 or the lipid phosphatase SHIP, and depends on their association with the BCR. Recent evidence shows that B-cell signal inhibition is regulated by ligand binding of inhibitory receptors.

📜 SIMILAR VOLUMES

Role of the CD28 receptor in T-cell acti

Role of the CD28 receptor in T-cell activation

✍ Carl H June; Jeffrey A Ledbetter; Peter S Linsley; Craig B Thompson 📂 Article 📅 1990 🏛 Elsevier Science 🌐 English ⚖ 964 KB

CD5 and other superantigens as ‘ticklers

CD5 and other superantigens as ‘ticklers’ of the B-cell receptor

✍ Richard Pospisil; Rose G. Mage 📂 Article 📅 1998 🏛 Elsevier Science 🌐 English ⚖ 316 KB

CD4, CD8 and the role of CD45 in T-cell

CD4, CD8 and the role of CD45 in T-cell activation

✍ Jeffrey A. Ledbetter; Julie P. Deans; Alejandro Aruffo; Laura S. Grosmaire; Stev 📂 Article 📅 1993 🏛 Elsevier Science 🌐 English ⚖ 1009 KB

CD4, CD8 and CD45 regulate the coupling of the T-cell receptor complex (CD3-TCR) to tyrosine kinase activation and phosphorylation of key substrates such as phospholipase C gamma 1. CD4 and CD8 contribute to activation signals through their cytoplasmic association with p56lck. Expression of the zeta

Role of B-cell and Fc receptors in the s

Role of B-cell and Fc receptors in the selection of T-cell epitopes

✍ Sebastian Amigorena; Christian Bonnerot 📂 Article 📅 1998 🏛 Elsevier Science 🌐 English ⚖ 510 KB

## Role of B-cell and Fc receptors in the selection of T-cell epitopes Sebastian Amigorena and Christian Bonnerot The role of specific receptors in antigen internalization and presentation to helper T lymphocytes has been known for more than ten years. However, recent work indicates that internali

Distribution of Several Activating and I

Distribution of Several Activating and Inhibitory Receptors on CD3−CD16+NK Cells and Their Correlation with NK Cell Function in Healthy Individuals

✍ Gordana Konjević; Katarina Mirjačić Martinović; Ana Vuletić; Vladimir Jurisić; I 📂 Article 📅 2009 🏛 Springer 🌐 English ⚖ 488 KB

B cell early response gene expression co

B cell early response gene expression coupled to B cell receptor, CD40 and interleukin-4 receptor co-stimulation: evidence for a role of the egr-2/krox20 transcription factor in B cell proliferation

✍ Joshua S. Newton; Jin Li; Zhi-Qiang Ning; Diana E. Schoendorf; John D. Norton; J 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 638 KB