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Role of the CD28 receptor in T-cell activation

✍ Scribed by Carl H June; Jeffrey A Ledbetter; Peter S Linsley; Craig B Thompson


Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
964 KB
Volume
11
Category
Article
ISSN
0167-5699

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CD4, CD8 and the role of CD45 in T-cell
✍ Jeffrey A. Ledbetter; Julie P. Deans; Alejandro Aruffo; Laura S. Grosmaire; Stev πŸ“‚ Article πŸ“… 1993 πŸ› Elsevier Science 🌐 English βš– 1009 KB

CD4, CD8 and CD45 regulate the coupling of the T-cell receptor complex (CD3-TCR) to tyrosine kinase activation and phosphorylation of key substrates such as phospholipase C gamma 1. CD4 and CD8 contribute to activation signals through their cytoplasmic association with p56lck. Expression of the zeta