✦ LIBER ✦

Role of B-cell and Fc receptors in the selection of T-cell epitopes

✍ Scribed by Sebastian Amigorena; Christian Bonnerot

Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 510 KB
Volume: 10
Category: Article
ISSN: 0952-7915
DOI: 10.1016/s0952-7915(98)80037-x

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✦ Synopsis

Role of B-cell and Fc receptors in the selection of T-cell epitopes Sebastian Amigorena and Christian Bonnerot

The role of specific receptors in antigen internalization and presentation to helper T lymphocytes has been known for more than ten years. However, recent work indicates that internalization may not always be sufficient for antigen presentation. Indeed, antigen receptors such as B-cell receptors and Fc receptors may also be involved in the post-endocytic transport events that determine selectively the delivery of antigens to different endocytic compartments and thereby the presentation of different T-cell epitopes.

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