The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis
β Scribed by A. M. Elsharkawy; F. Oakley; D. A. Mann
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 369 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1360-8185
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In fibroblasts, thrombin induces collagen deposition through activation of a G-protein-coupled receptor, proteinase-activated receptor 1 (PAR(1)). In the current study, we examined whether PAR(1) antagonism inhibits hepatic stellate cell (HSC) activation in vitro and whether it protects against fibr