Background & Aims: The ligand-dependent transcription factor peroxisome proliferator-activated receptor gamma (PPARgamma) is expressed in hepatic stellate cells (HSC), and its transcriptional activity is reduced during cell transdifferentiation in culture. PPARgamma transcriptional activation decrea
โฆ LIBER โฆ
Hepatic stellate cells: a target for the treatment of liver fibrosis
โ Scribed by Jian Wu; Mark A. Zern
- Publisher
- Springer Japan
- Year
- 2000
- Tongue
- English
- Weight
- 93 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0944-1174
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Hepatic stellate cell activation is a main feature of liver fibrogenesis. We have previously shown that phagocytosis of apoptotic bodies by stellate cells induces procollagen โฃ1 (I) and transforming growth factor beta (TGF-โค) expression in vitro. Here we have further investigated the downstream effe