Recurrent hepatitis C after liver transplantation is a serious problem faced by liver transplant recipients. Activation of hepatic stellate cells is an early step in hepatic fibrogenesis. The aim of this study was to evaluate hepatic stellate cell activation, early after liver transplantation, as a
Activated hepatic stellate cells participate in liver fibrosis in a patient with transfusional iron overload
β Scribed by Yoshinori Harada; Masaki Iwai; Masamichi Kakusui; Takahiro Mori; Kazunobu Tada; Yasutaka Ishii; Takeshi Okanoue; Kei Kashima
- Publisher
- Springer Japan
- Year
- 1998
- Tongue
- English
- Weight
- 330 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0944-1174
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The pathogenic mechanisms of accelerated graft fibrosis in hepatitis C recurrence after liver transplantation (LT) are not well established. The aim of the study was to assess whether a greater activation of hepatic stellate cells (HSC), the major collagen-producing cells in the liver, can occur in
Hepatic stellate cell activation is a main feature of liver fibrogenesis. We have previously shown that phagocytosis of apoptotic bodies by stellate cells induces procollagen β£1 (I) and transforming growth factor beta (TGF-β€) expression in vitro. Here we have further investigated the downstream effe