The rodent dominant-lethal assay
β Scribed by W. M. Generoso
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 219 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0893-6692
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Pregnant C3H mice were orally treated with 50 mg Trypaflavin/kg on day 7, 11, 14, or 15 post conception. The embryos were thus treated in utero with the test compound. At the age of 10 weeks, the dominant lethal assay was performed with F1 females. Dominant lethal mutations were induced only in thos
Dominant lethal mutations are due to chromosome aberrations as demonstrated by analysis of first cleavage. With a sample size of 40-45 mice per dose the induction of dominant lethal mutations by 10 mg/kg of methyl methanesulfonat (MMS) can be detected in spermatids in the mating interval 9-12 days p