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The Risk of Developing Ankylosing Spondylitis in HLA-B27 Positive Individuals: A Family and Population Study

✍ Scribed by van der Linden, S.; Valkenburg, H.; Cats, A.

Book ID
124153061
Publisher
Oxford University Press
Year
1983
Tongue
English
Weight
167 KB
Volume
XXII
Category
Article
ISSN
1462-0324

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## Abstract The present study was performed on 61 HLA‐B27 positive first‐degree relatives and 40 HLA‐B27 negative relatives of 20 HLA‐B27 positive probands with ankylosing spondylitis (AS). Of 24 HLA‐B27 positive relatives 45 years or older, 21% had AS and 38% sacroiliitis. The HLA‐B27 negative rel

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## Objective: To determine whether hla-b27 positive patients with ankylosing spondylitis (as) and reactive arthritis (rea) share additional hla factors that confer disease susceptibility. ## Methods: Hla class i antigens were typed serologically, and class ii antigens molecularly, in samples take