HLA-B27 haplotypes in family studies of ankylosing spondylitis
β Scribed by John A. Lochead; Dr Ian M. Chalmers; William H. Marshall; Bodil Larsen; Verna M. Skanes; Ronald H. Payne; John M. Barnard
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 515 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0004-3591
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## Objective: To determine whether hla-b27 positive patients with ankylosing spondylitis (as) and reactive arthritis (rea) share additional hla factors that confer disease susceptibility. ## Methods: Hla class i antigens were typed serologically, and class ii antigens molecularly, in samples take
We examined the distribution of non-B27 alleles of the HLA-B locus among B27+ patients with ankylosing spondylitis (AS), to detect any additional HLA-B locus allele(s) that may act in conjunction with B27 to increase susceptibility to AS. HLA-Bw60 (or B40 when the Bw60,61 split of B40 was not typed
## Abstract The present study was performed on 61 HLAβB27 positive firstβdegree relatives and 40 HLAβB27 negative relatives of 20 HLAβB27 positive probands with ankylosing spondylitis (AS). Of 24 HLAβB27 positive relatives 45 years or older, 21% had AS and 38% sacroiliitis. The HLAβB27 negative rel