HLA–Bw60 increases susceptibility to ankylosing spondylitis in HLA–B27+ patients

✍ Scribed by Wendy P. Robinson; Sjef M. Van Der Linden; Professor of Medicine Muhammad A. Khan; Hans-Ueli Rentsch; Professor of Medicine; Chairman Arnold Cats; Professor of Medicine Anthony Russell; Professor of Genetics Glenys Thomson

• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 624 KB
• Volume: 32
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/anr.1780320912

✦ Synopsis

We examined the distribution of non-B27 alleles of the HLA-B locus among B27+ patients with ankylosing spondylitis (AS), to detect any additional HLA-B locus allele(s) that may act in conjunction with B27 to increase susceptibility to AS. HLA-Bw60 (or B40 when the Bw60,61 split of B40 was not typed for) was shown to be increased among B27+ AS patients in each of 5 independent data sets. This increase was statistically significant in 4 of the 5 data sets studied, and the overall significance was P < 0.00001. Susceptibility to AS in B27+ individuals was further increased by a factor of -3 when Bw60 was also present. The distribution of HLA-A alleles on the B27-bearing haplotypes in AS patients was not significantly different from that in From the