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The Risk of Central Nervous System Metastases After Trastuzumab Therapy in Patients With Breast Carcinoma

✍ Scribed by Melisko, M.E.

Book ID
122515773
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
67 KB
Volume
16
Category
Article
ISSN
1043-321X

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## Abstract ## BACKGROUND Trastuzumab, which is a large monoclonal antibody that is efficacious in the treatment of patients with HER‐2/__neu__‐overexpressing, metastatic breast carcinoma, does not penetrate the blood‐brain barrier and, thus, may allow the brain to become a sanctuary site for micr