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Central nervous system metastases in women after multimodality therapy for high risk breast cancer

✍ Scribed by Lisa A. Carey; Matthew G. Ewend; Richard Metzger; Lynda Sawyer; E. Claire Dees; Carolyn I. Sartor; Dominic T. Moore; Mark L. Graham


Publisher
Springer US
Year
2004
Tongue
English
Weight
142 KB
Volume
88
Category
Article
ISSN
0167-6806

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## Abstract ## BACKGROUND Trastuzumab, which is a large monoclonal antibody that is efficacious in the treatment of patients with HER‐2/__neu__‐overexpressing, metastatic breast carcinoma, does not penetrate the blood‐brain barrier and, thus, may allow the brain to become a sanctuary site for micr