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Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma

✍ Scribed by Johanna C. Bendell; Susan M. Domchek; Harold J. Burstein; Lyndsay Harris; Jerry Younger; Irene Kuter; Craig Bunnell; Montse Rue; Rebecca Gelman; Eric Winer

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 77 KB
Volume: 97
Category: Article
ISSN: 0008-543X
DOI: 10.1002/cncr.11436

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## Abstract ## BACKGROUND Trastuzumab, which is a large monoclonal antibody that is efficacious in the treatment of patients with HER‐2/__neu__‐overexpressing, metastatic breast carcinoma, does not penetrate the blood‐brain barrier and, thus, may allow the brain to become a sanctuary site for micr